I’ve been asked a few times how I stay on top of GitHub:
This works well for me, it may work for you.
What I miss is Bugzilla’s needinfo. I could see this as a persistent notification that cannot be dismissed until you go into the thread and perform the action asked of you. What I also miss on /notifications is the ability to see if someone mentioned me in a thread. I often want to unsubscribe based on the title, but I don’t always do it out of fear of neglecting someone.